May River Preserve Homes for Sale

Welcome to May River Preserve, a stunning and serene subdivision nestled in the heart of Bluffton, South Carolina. This picturesque community is the epitome of Lowcountry living, offering residents a perfect blend of nature, luxury, and convenience. Surrounded by lush landscapes and the tranquil waters of the May River, this area is a haven for those seeking a peaceful retreat while still being close to the vibrant culture and amenities of Bluffton.

Homes for sale in May River Preserve reflect the charm and elegance of Southern architecture, featuring spacious layouts and modern finishes that cater to today’s discerning buyers. You’ll find a variety of floor plans that suit diverse lifestyles, whether you’re a growing family, a retiree, or a young professional. Each home is thoughtfully designed to maximize comfort and functionality, with many boasting stunning outdoor spaces perfect for entertaining or simply enjoying the breathtaking views of the natural surroundings.

As a resident of May River Preserve, you’ll enjoy access to a wealth of amenities, including walking trails, community parks, and proximity to the beautiful May River, ideal for kayaking, fishing, and leisurely strolls along the water. Bluffton's charming downtown area, filled with delightful shops, restaurants, and cultural attractions, is just a short drive away, ensuring you have everything you need at your fingertips.

Discover your dream home in May River Preserve today, where comfort, community, and the beauty of the Lowcountry await you!

Newest May River Preserve Homes for Sale

$885,000

4 Beds ⋅ 4 Baths ⋅ 197928 MLS

This is the May River Preserve home buyers have been waiting for! The gorgeous, just-renovated kitchen features quartz counters, freshly painted cabinetry, a new hood, hardware, and pendant lights. Set on over half an acre, this 4-bedroom, 3.5-bath home offers wooded views in front and a large fenced backyard overlooking the lagoon. The showstopping lanai is one of the largest in the community and creates an incredible outdoor living space. Inside, soaring ceilings add to the sense of space, and nearly the entire interior has fresh paint. The main-floor primary suite includes a custom closet. Upstairs are 3 bedrooms, 2 baths, a loft, huge walk-in storage, and a color-drenched bonus room with a built-in library. Enjoy the privacy, space, and amenities of gated May River Preserve.

36 Daffodil Farm Road, Bluffton

Courtesy of Collins Group Realty, from Lowcountry Regional MLS.

Start Your Search

We do not attempt to independently verify the currency, completeness, accuracy or authenticity of the data contained herein. It may be subject to transcription and transmission errors. Accordingly, the data is provided on an “as is” “as available” basis only and may not reflect all real estate activity in the market. © 2026 REsides, Inc. All rights reserved. Certain information contained herein is derived from information, which is the licensed property of, and copyrighted by, REsides, Inc.

This information is deemed reliable, but not guaranteed. Neither the Lowcountry Regional MLS, nor the listing broker, nor their agents or subagents are responsible for the accuracy of the information. The buyer is responsible for verifying all information. This information is provided by the Lowcountry Regional MLS for use by its members and is not intended for use for any other purpose.